Zhen Zhao

报告题目：《Comprehensive analysis of blood factors during pregnancy and fetal brain development》

职称：Associate Professor

职务：Program director

工作单位：National Institutes of Health Clinical Center

专业特长：The development and application of group technology and biomarkers based on mass spectrometry and molecular biology

报告内容：Pregnancy induces marked systemic changes in plasma hormone and protein concentrations. Essential nutrients are also important determinants of health of both mother and offspring. Important events in fetal development occur during each of the three trimesters. This presentation will describe the profiling of factors critical to maintaining normal pregnancy and/or fetal brain development.

David Sacks

报告题目：《Gestational diabetes mellitus（妊娠期糖尿病）》

职称：Senior Investigator

职务：Chief

工作单位：National Institutes of Health

专业特长：diabetes mellitus

报告内容：Gestational diabetes mellitus (GDM) has been defined as “any degree of glucose intolerance with onset or first recognition during pregnancy”. The reason to identify GDM is that it produces complications for both the fetus (e.g., large baby, neonatal hypoglycemia) and mother (e.g., pre-eclampsia, increased risk of cesarean delivery and markedly increased likelihood of subsequent type 2 diabetes). Treatment of GDM reduces some of the adverse outcomes. There is considerable controversy around the best way toidentify women with GDM. Both the screening and diagnostic criteria vary among countries and often differ between obstetric and diabetes organizations in a single country. Recommendations for screening range from “do not screen” to selective screening (high risk only) to universal screening (screen everyone). Moreover, the techniques used for screening vary; fasting glucose, random glucose and oral glucose challenge are all used. The criteria for diagnosis are even more controversial. The major items of contention are the number of steps (1 or 2), the glucose load (75 g or 100 g), the duration of the test (2 h or 3 h), the glucose cutoff values and whether 1 or 2 high glucose values are required.

翟燕红

报告题目：《串联质谱在PCOS患者中检测睾酮的应用》

职称：副主任技师

职务：主任

工作单位：首都医科大学附属北京妇产医院

专业特长：医学检验学

报告内容：多囊卵巢综合征（PCOS）是女性最常见的内分泌疾病。直接测量具有生物活性的游离睾酮(FT)对诊断治疗PCOS 具有重要的临床意义。目前国际上用于检测FT的金标准方法是直接放射免疫法，但此方法具有放射性危害，不适于推广应用。随着液相色谱串联质谱(LC--MS/MS)在临床的推广和普及，在此设备上开展FT检测将是特异度和灵敏度非常好的一种最新的方法学的开发。为临床提供高通量准确的实验室结果，提高PCOS 的诊断的准确率。

Zhaoxia Ren

报告题目：《Safe and Effective Medications in Pregnant Women》

职称：Program Director

工作单位：The Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health (NIH)

专业特长：Obstetrics and Pediatrics Pharmacology and Therapeutics

报告内容：Pharmacoepidemiological surveys indicate that nearly two-thirds of all pregnant women take up to four medications either by prescription or over-the-counter during pregnancy and labor. Most of such medication use is either off-label or based on an empiric understanding of dosing, safety, and efficacy rather than based on well-designed and carefully monitored clinical studies/trials during pregnancy. In addition, pregnancy induces extensive physiological and biochemical changes that involve the mother, placenta, and the fetus and typically lead to variations in the absorption, distribution, and elimination of drugs as well as response to treatment. Current therapeutic practice has not taken into account these profound physiological and biochemical changes in pregnant women. Despite progress on developingtailored therapeutics for obstetric patients in recent years, information guiding safe and effective drug therapy for obstetric patients remains incomplete. This session is intended to give a high-level overview of the efforts and approaches that the National Institutes of Health (NIH) made to address this unmet medical need in the United States.

赵正言

报告题目：《新生儿遗传代谢病筛查进展和精准医学》

职称：教授

职务：院长

工作单位：浙江大学附属儿童医院

专业特长：儿科疾病诊疗

报告内容：国内外新生儿疾病筛查进展，包括：串联质谱新生儿筛查，以及最新的DMD/LSD/SCID/NGS等技术在新筛领域应该。

朱宇宁

报告题目：《高龄妊娠的产前诊断与遗传咨询》

职称：主任技师

职务：科主任

工作单位：工作单位：浙江大学医学院附属妇产科医院

专业特长：专业特长：分子诊断、产前诊断、生殖遗传咨询

报告内容：报告内容：高龄孕妇的胎儿染色体非整倍体等遗传异常风险增加，是产前诊断的主要人群。产前诊断有传统的染色体核型技术、快速诊断技术（FISH、QF-PCF等）、染色体芯片技术等，应如何选择？每种技术都有其优势也有其局限性，透彻了解才能清楚风险，“适宜的”才是最好的选择。

Joely A. Straseski

报告题目：《Assessing Ovarian Reserve: From FSH to AMH?》

职称：Associate Professor

职务：Medical Director

工作单位：University of Utah School of Medicine

报告内容：Infertility is a complex issue that affects a striking number of couples. The causes of infertility are often multifactorial and statistics show that the incidence is only increasing. There are biological, psychological, and financial ramifications that all need to be considered as we approach this problem on an international level. The clinical assessment of infertility in women often involves a physical exam and measurement of several hormones. Follicle stimulating hormone (FSH) and estradiol (E2) have long been used in fertility investigations, but each has its limitations. Anti-Müllerian hormone (AMH) is produced by immature ovarian follicles in the female and is correlated with a woman’s “ovarian reserve,” or size and quality of the ovarian follicle pool. AMH’s use as a newer biomarker of overall fertility and even as a proposed predictor of menopause has been well documented in the literature. Additionally, it is suggested to have utility as a predictor of ovarian response in in vitro fertilization procedures.

罗燕萍

报告题目：《儿童呼吸道病原的快速诊断》

职称：主任技师

职务：科主任

工作单位：解放军总医院微生物科

专业特长：临床微生物与免疫

报告内容：儿童呼吸道病原严重威胁着儿童的健康，临床早期诊断十分重要，本次就呼吸道病原的快速检测方法进行阐述，系统分析了解目前这方面的临床应用及价值。

Shannon Haymond

报告题目：《Mass spectrometry: A clinical tool for babies and beyond》

职称：Assistant professor

职务：Director

工作单位：Northwestern University Feinberg School of Medicine，Ann & Robert H. Lurie Children’s Hospital of Chicago

专业特长：evaluation and utilization of novel biomarkers in pediatric diseases

报告内容：This presentation will review the role of clinical mass spectrometry methods in children’s health. The use of mass spectrometry in clinical laboratories continues to grow and offers many advantages for pediatric populations. Cases will be used to illustrate the varied and valuable ways mass spectrometry-based testing supports medical care of infants, children, and adolescents. Challenges that must be overcome for continued adoption of mass spectrometry in clinical laboratories will also be discussed.

崔丽艳

报告题目：《抗磷脂抗体谱与病态妊娠》

职称： 副主任医师

职务： 副主任

工作单位：北京大学第三医院

专业特长：临床免疫学检验

报告内容： 病态妊娠主要见于产科APS。抗磷脂抗体是指能与多种含磷脂的抗原（靶蛋白）发生免疫反应的抗体，抗磷脂抗体与滋养层细胞结合，启动经典途径激活补体，导致胎盘受损，最终出现死胎、流产、宫内发育受限等。

李海霞

报告题目：《一项多中心儿童常用检验指标参考区间的建立》

职称：副研究员

职务： 主任

工作单位：北京大学第一医院

专业特长：临床生物化学与分子检验

报告内容：目前我国儿童检验项目所依据的参考区间多是借用成人参考区间或来自于国内既往儿科分散、小样本研究，且多部分性别、年龄采用固定、统一的参考区间，本研究由北京大学第一医院儿科联合国内14个省市的20家医学中心，招募并筛选近2000名儿童，进行问卷调查、体格检查及血液检查，选择临床常规使用，与儿童生长发育和脏器功能相关的检验指标， 初步建立我国儿童的参考区间数据。

许红

报告题目：《浅谈检验科质量管理新理念》

职务：科主任

工作单位：石家庄市第四医院检验科

专业特长：医学检验学

报告内容：随着国民整体素质的提高和医学的飞速发展，新理念、新思维、新技术、新设备已被广泛引入检验医学领域，检验医学呈现突飞猛进的发展态势。现代“检验医学”已逐渐摆脱了传统以“标本为中心”，以实验数据为目的的“医学检验”，而成为以“患者为中心”，以“疾病诊断、治疗、预防、咨询”为目的的学科。但目前检验医学队伍存在管理上、技能上、人员素质上的参差不齐，滞后于与国际化的接轨。讲者浅析了检验科在适应现代医学形势和患者需求方面提出了一些新的管理思路和理念。