the Department of Laboratory Medicine, Beijing Obstetrics and Gynecology Hospital
Name: Lican Han
Titile：Comprehensive analysis of blood factors during pregnancy and fetal brain development
Position：Associate Professor，Program director
Unit：National Institutes of Health Clinical Center
Research interest：The development and application of group technology and biomarkers based on mass spectrometry and molecular biology
Abtract：Pregnancy induces marked systemic changes in plasma hormone and protein concentrations. Essential nutrients are also important determinants of health of both mother and offspring. Important events in fetal development occur during each of the three trimesters. This presentation will describe the profiling of factors critical to maintaining normal pregnancy and/or fetal brain development.
Titile：Gestational diabetes mellitus
Position：Senior Investigator and Chief of Clinical Chemistry at the NIH
Unit：National Institutes of Health
Research interest：diabetes mellitus
Abtract：Gestational diabetes mellitus (GDM) has been defined as “any degree of glucose intolerance with onset or first recognition during pregnancy”. The reason to identify GDM is that it produces complications for both the fetus (e.g., large baby, neonatal hypoglycemia) and mother (e.g., pre-eclampsia, increased risk of cesarean delivery and markedly increased likelihood of subsequent type 2 diabetes). Treatment of GDM reduces some of the adverse outcomes. There is considerable controversy around the best way toidentify women with GDM. Both the screening and diagnostic criteria vary among countries and often differ between obstetric and diabetes organizations in a single country. Recommendations for screening range from “do not screen” to selective screening (high risk only) to universal screening (screen everyone). Moreover, the techniques used for screening vary; fasting glucose, random glucose and oral glucose challenge are all used. The criteria for diagnosis are even more controversial. The major items of contention are the number of steps (1 or 2), the glucose load (75 g or 100 g), the duration of the test (2 h or 3 h), the glucose cutoff values and whether 1 or 2 high glucose values are required.
Titile：Application of tandem mass spectrometry in the detection of testosterone in PCOS patients.
Position：Clinical laboratory director
Unit：Beijing obstetrics and gynecology hospital, capital medical university
Research interest：Medical testing
Abtract：Polycystic ovary syndrome (PCOS) is the most common endocrine disease in women. Direct measurement of biologically active free testosterone (FT) has important clinical significance in the diagnosis and treatment of PCOS. At present, the international standard method for detecting FT is direct radioimmunoassay, but this method is radioactive and is not suitable for popularization and application. With the rapid development and popularization of LC - MS / MS, FT detection on this device will be a very good method and will provide high - throughput and accurate results for clinical practice, and ultimately improve the diagnostic accuracy of PCOS.
Titile：Safe and Effective Medications in Pregnant Women.
Unit：The Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health (NIH)
Research interest：Obstetrics and Pediatrics Pharmacology and Therapeutics
Abtract：Pharmacoepidemiological surveys indicate that nearly two-thirds of all pregnant women take up to four medications either by prescription or over-the-counter during pregnancy and labor. Most of such medication use is either off-label or based on an empiric understanding of dosing, safety, and efficacy rather than based on well-designed and carefully monitored clinical studies/trials during pregnancy. In addition, pregnancy induces extensive physiological and biochemical changes that involve the mother, placenta, and the fetus and typically lead to variations in the absorption, distribution, and elimination of drugs as well as response to treatment. Current therapeutic practice has not taken into account these profound physiological and biochemical changes in pregnant women. Despite progress on developingtailored therapeutics for obstetric patients in recent years, information guiding safe and effective drug therapy for obstetric patients remains incomplete. This session is intended to give a high-level overview of the efforts and approaches that the National Institutes of Health (NIH) made to address this unmet medical need in the United States.
Titile：Advances in neonatal genetic metabolic disease screening and precision medicine
Position：Professor， Hospital Dean
Unit：The children’s hospital zhejiang university school of medicine.
Research interest：Pediatric disease diagnosis and treatment
Abtract：The recent progress of neonatal disease screening, including: tandem mass spectrometry neonatal screening, as well as the latest DMD / LSD / SCID / NGS and other technologies in the newborn screening area.
Titile：Prenatal diagnosis and genetic counseling for advanced pregnancy.
Unit：Hangzhou maternity and child health care hospital
Research interest：Molecular diagnosis, prenatal diagnosis, reproductive genetic counseling
Abtract：Pregnant women with fetal chromosome aneuploidy and other genetic abnormalities increased, and is the main population of prenatal diagnosis. There are a variety of techniques available for prenatal diagnosis, including traditional chromosome karyotyping techniques, rapid diagnostic techniques (FISH, QF-PCF, etc.), chromosome chip technology, etc. How should We choose?
Joely A. Straseski
Titile：Assessing Ovarian Reserve: From FSH to AMH?
Position：Associate Professor, Pathology Medical Director, EndocrinologyCo-Medical Director, Core Laboratory
Unit：University of Utah School of Medicine
Abtract：Infertility is a complex issue that affects a striking number of couples. The causes of infertility are often multifactorial and statistics show that the incidence is only increasing. There are biological, psychological, and financial ramifications that all need to be considered as we approach this problem on an international level. The clinical assessment of infertility in women often involves a physical exam and measurement of several hormones. Follicle stimulating hormone (FSH) and estradiol (E2) have long been used in fertility investigations, but each has its limitations. Anti-Müllerian hormone (AMH) is produced by immature ovarian follicles in the female and is correlated with a woman’s “ovarian reserve,” or size and quality of the ovarian follicle pool. AMH’s use as a newer biomarker of overall fertility and even as a proposed predictor of menopause has been well documented in the literature. Additionally, it is suggested to have utility as a predictor of ovarian response in in vitro fertilization procedures.
Titile：Rapid diagnosis of children's respiratory diseases.
Unit：Medical school of chinese PLA
Research interest：Clinical Microbiology and Immunity
Abtract：Children's respiratory pathology is a serious threat to the health of children, clinical early diagnosis is very important, I will elaborate on the rapid detection of respiratory pathogens, and systematically analyze its clinical application and value.
Titile：Mass spectrometry: A clinical tool for babies and beyond
Unit：Northwestern University Feinberg School of Medicine，Ann & Robert H. Lurie Children’s Hospital of Chicago
Research interest：evaluation and utilization of novel biomarkers in pediatric diseases
Abtract：This presentation will review the role of clinical mass spectrometry methods in children’s health. The use of mass spectrometry in clinical laboratories continues to grow and offers many advantages for pediatric populations. Cases will be used to illustrate the varied and valuable ways mass spectrometry-based testing supports medical care of infants, children, and adolescents. Challenges that must be overcome for continued adoption of mass spectrometry in clinical laboratories will also be discussed.
Titile：The establishment of a reference interval for the common test indicators in child of a multi-center.
Position： Associate investigator, director
Unit：Peking university first hospital
Research interest：Clinical biochemistry and molecular testing
Abstract：At present, the reference interval of test item on children in China is mainly based on the reference interval of adult or the former fragmentary research on paediatrics, and the reference interval isn’t subdivided according to the age or gender of the children. The study, led by the department of pediatric of Peking University First Hospital and joined with 20 medical centers of 14 provinces and cities in China, recruited and screened nearly 2,000 children to conduct questionnaires and implement physical examination and blood tests. The study initially established the reference interval data of children in China.
Titile：Anti-phospholipid antibody spectrum and pathological pregnancy.
Unit：Peking university third hospital
Research interest：Clinical immunology test
Abtract：Sick pregnancy is mainly seen in obstetric APS. Antiphospholipid antibodies are antibodies that react with a variety of phospholipid-containing antigens (target proteins), antiphospholipid antibodies bind to trophoblast cells, initiate classical pathways to activate complement, resulting in impaired placenta, eventually occurring stillbirth, abortion, maternal Within the development of limited.
Titile：A brief discussion on the new concept of quality management of clinical lab.
Unit：The Fourth Hospital of Shijiazhuang
Research interest：Medical testing
Abtract：With the introduction of new concepts, technologies and equipments, the development of medical science has been developed rapidly. Specimens are no longer as the center of Modern laboratory medicine, experimental data is no longer the purpose of medical test, instead, patients become the center, and "disease diagnosis, treatment, prevention, counseling" become the purpose of laboratory medicine. However, there are many problems in the management, skills, and personnel quality of medical teams, which affect the internationalization..How to adapt to the modern medical situation and the demand of patient? The speaker put forward some new management ideas.